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KMID : 0358920090360030433
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Journal of the Korean Academy of Pedodontics
2009 Volume.36 No. 3 p.433 ~ p.439
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THE MANDIBULAR GROWTH EFFECT OF THE BOTULINUM TOXIN TYPE A INJECTION INTO UNILATERAL MASSSTER MUSCLE OF GROWING RAT
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Quark So-Youn
Park Ki-Tae
Kim Ji-Yeon
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Abstract
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The purpose of this study was to assess the effect on mandibular growth of botulinum toxin type A (BTXA) injection into the unilateral massester muscle of growing rats at three different growing stages. Thirty six male Sprague-Dawley rats were divided into three groups according to the age (group 1: 4 weekold, group 2: 5week-old, group 3: 6week-old). Then each group was randomly divided into 3 subgroups (control group, unilateral injection group, bilateral injection group). Experimental animals were sacrificed after 4 weeks. Then the jaw measurements were evaluated. The results were as follows: 1. In the group 1, mandibular body length, condylar height and coronoid process height of the unilateral group(BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 2. In the group 2, anterior region height, condylar height, coronoid process height of the unilateral group (BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 3. In the group 3, mandibular body length, condylar height, coronoid process height of the unilateral group (BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 4. There was no significant difference in mandibular measurements between the control side and the injection side in the unilateral group in all age groups (p>0.05).
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KEYWORD
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Botulinum type A toxin, Mandibular growth, Functional matrix
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